Mitochondrial Transplantation by Intra-Arterial Injection for Acute Kidney Injury
在接受粒線體轉植治療後24小時，腎小球濾過率和尿量顯著增加，而血清肌酐和血尿素氮顯著降低。
After 24 hours, estimated glomerular filtration rate and urine output were significantly increased while serum creatinine and blood urea nitrogen were significantly decreased in swine receiving mitochondria as compared to those receiving vehicle.
主要結論：
- 線粒體移植防止了I/R引起的腎組織損害。
- 線粒體移植增強了I/R損傷後腎細胞的再生能力。
- 線粒體移植阻止了I/R誘導的腎細胞凋亡。
- 線粒體移植未來可能急性腎臟損傷(AKI)的新型治療技術。
Am J Physiol Renal Physiol. 2020 Jul 20.
Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease. 1866:8,2020